Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity Export

@article{Wang:2003p966, abstract = {In contrast to the well-established roles of PPARgamma and PPARalpha in lipid metabolism, little is known for PPARdelta in this process. We show here that targeted activation of PPARdelta in adipose tissue specifically induces expression of genes required for fatty acid oxidation and energy dissipation, which in turn leads to improved lipid profiles and reduced adiposity. Importantly, these animals are completely resistant to both high-fat diet-induced and genetically predisposed (Lepr(db/db)) obesity. As predicted, acute treatment of Lepr(db/db) mice with a PPARdelta agonist depletes lipid accumulation. In parallel, PPARdelta-deficient mice challenged with high-fat diet show reduced energy uncoupling and are prone to obesity. In vitro, activation of PPARdelta in adipocytes and skeletal muscle cells promotes fatty acid oxidation and utilization. Our findings suggest that PPARdelta serves as a widespread regulator of fat burning and identify PPARdelta as a potential target in treatment of obesity and its associated disorders.}, author = {Wang, Yong X. and Lee, Chih H. and Tiep, Sambath and Yu, Ruth T. and Ham, Jungyeob and Kang, Heonjoong and Evans, Ronald M.}, citeulike-article-id = {3046189}, citeulike-linkout-0 = {http://linkinghub.elsevier.com/retrieve/pii/S0092867403002691}, journal = {Cell}, keywords = {acids, adipose, and, animals, body, brown, cell, cytoplasmic, dietary, energy, factors, fats, fatty, file-import-08-07-27, food, formulated, fusion, genetic, knockout, leptin, lipid, metabolism, mice, nuclear, obesity, proteins, receptors, recombinant, surface, thiazoles, tissue, transcription, transgenes, transgenic, triglycerides, vectors, weight}, local-url = {file://localhost/Users/ken/Documents/Papers/2003/Wang/Cell\%202003\%20Wang.pdf}, month = {Apr}, number = {2}, pages = {159--70}, posted-at = {2008-07-27 14:46:03}, priority = {2}, title = {Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity}, url = {http://linkinghub.elsevier.com/retrieve/pii/S0092867403002691}, volume = {113}, year = {2003} }

TY - JOUR ID - Wang:2003p966 L3 - citeulike-article-id:3046189 N2 - In contrast to the well-established roles of PPARgamma and PPARalpha in lipid metabolism, little is known for PPARdelta in this process. We show here that targeted activation of PPARdelta in adipose tissue specifically induces expression of genes required for fatty acid oxidation and energy dissipation, which in turn leads to improved lipid profiles and reduced adiposity. Importantly, these animals are completely resistant to both high-fat diet-induced and genetically predisposed (Lepr(db/db)) obesity. As predicted, acute treatment of Lepr(db/db) mice with a PPARdelta agonist depletes lipid accumulation. In parallel, PPARdelta-deficient mice challenged with high-fat diet show reduced energy uncoupling and are prone to obesity. In vitro, activation of PPARdelta in adipocytes and skeletal muscle cells promotes fatty acid oxidation and utilization. Our findings suggest that PPARdelta serves as a widespread regulator of fat burning and identify PPARdelta as a potential target in treatment of obesity and its associated disorders. IS - 2 JF - Cell EP - 70 TI - Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity VL - 113 SP - 159 KW - acids KW - adipose KW - and KW - animals KW - body KW - brown KW - cell KW - cytoplasmic KW - dietary KW - energy KW - factors KW - fats KW - fatty KW - file-import-08-07-27 KW - food KW - formulated KW - fusion KW - genetic KW - knockout KW - leptin KW - lipid KW - metabolism KW - mice KW - nuclear KW - obesity KW - proteins KW - receptors KW - recombinant KW - surface KW - thiazoles KW - tissue KW - transcription KW - transgenes KW - transgenic KW - triglycerides KW - vectors KW - weight AU - Wang, Yong AU - Lee, Chih AU - Tiep, Sambath AU - Yu, Ruth AU - Ham, Jungyeob AU - Kang, Heonjoong AU - Evans, Ronald PY - 2003/Apr// UR - http://linkinghub.elsevier.com/retrieve/pii/S0092867403002691 ER -