ErbB receptors: new insights on mechanisms and biology Export

@article{citeulike:968369, abstract = {The ErbB family of four receptor tyrosine kinases occupies a central role in a wide variety of biological processes from neuronal development to breast cancer. New information continues to expand their biologic significance and to unravel the molecular mechanisms that underlie the signaling capacity of these receptors. Here, we review several aspects of ErbB receptor physiology for which new and significant information is available. These include ligand-dependent receptor dimerization and kinase activation, which is a prerequisite for all subsequent growth factor-dependent cell responses. We also address novel roles of receptor fragments in signaling, trafficking to intracellular sites, such as the nucleus, and ErbB roles in non-cancer disease processes, including schizophrenia, chronic renal disease, hypertension, and the cellular entry of infectious pathogens.}, author = {Linggi, Bryan and Carpenter, Graham}, citeulike-article-id = {968369}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tcb.2006.10.008}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6TCX-4M936FV-2/2/b2ef1e2e7bd785dc706f72054378b6cb}, doi = {10.1016/j.tcb.2006.10.008}, journal = {Trends in Cell Biology}, keywords = {cancer, drug, erbb-receptors}, month = {December}, number = {12}, pages = {649--656}, posted-at = {2006-11-30 08:23:22}, priority = {2}, title = {ErbB receptors: new insights on mechanisms and biology}, url = {http://dx.doi.org/10.1016/j.tcb.2006.10.008}, volume = {16}, year = {2006} }

TY - JOUR ID - citeulike:968369 L3 - citeulike-article-id:968369 N2 - The ErbB family of four receptor tyrosine kinases occupies a central role in a wide variety of biological processes from neuronal development to breast cancer. New information continues to expand their biologic significance and to unravel the molecular mechanisms that underlie the signaling capacity of these receptors. Here, we review several aspects of ErbB receptor physiology for which new and significant information is available. These include ligand-dependent receptor dimerization and kinase activation, which is a prerequisite for all subsequent growth factor-dependent cell responses. We also address novel roles of receptor fragments in signaling, trafficking to intracellular sites, such as the nucleus, and ErbB roles in non-cancer disease processes, including schizophrenia, chronic renal disease, hypertension, and the cellular entry of infectious pathogens. IS - 12 JF - Trends in Cell Biology EP - 656 TI - ErbB receptors: new insights on mechanisms and biology VL - 16 SP - 649 KW - cancer KW - drug KW - erbb-receptors AU - Linggi, Bryan AU - Carpenter, Graham PY - 2006/12// UR - http://dx.doi.org/10.1016/j.tcb.2006.10.008 ER -