Tissue-specific transcriptional regulation has diverged significantly between human and mouse. Export

@article{citeulike:1342798, abstract = {We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A and HNF6) to 4,000 orthologous gene pairs in hepatocytes purified from human and mouse livers. Despite the conserved function of these factors, from 41\% to 89\% of their binding events seem to be species specific. When the same protein binds the promoters of orthologous genes, approximately two-thirds of the binding sites do not align.}, author = {Odom, Duncan T. and Dowell, Robin D. and Jacobsen, Elizabeth S. and Gordon, William and Danford, Timothy W. and MacIsaac, Kenzie D. and Rolfe, P. Alexander and Conboy, Caitlin M. and Gifford, David K. and Fraenkel, Ernest}, citeulike-article-id = {1342798}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng2047}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng2047}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17529977}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17529977}, day = {21}, doi = {10.1038/ng2047}, issn = {1061-4036}, journal = {Nature genetics}, keywords = {chipchip, hnf4, odom, young}, month = {June}, number = {6}, pages = {730--732}, posted-at = {2008-01-03 23:12:42}, priority = {2}, publisher = {Nature Publishing Group}, title = {Tissue-specific transcriptional regulation has diverged significantly between human and mouse.}, url = {http://dx.doi.org/10.1038/ng2047}, volume = {39}, year = {2007} }

TY - JOUR ID - citeulike:1342798 L3 - citeulike-article-id:1342798 N2 - We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A and HNF6) to 4,000 orthologous gene pairs in hepatocytes purified from human and mouse livers. Despite the conserved function of these factors, from 41% to 89% of their binding events seem to be species specific. When the same protein binds the promoters of orthologous genes, approximately two-thirds of the binding sites do not align. IS - 6 JF - Nature genetics SN - 1061-4036 EP - 732 TI - Tissue-specific transcriptional regulation has diverged significantly between human and mouse. PB - Nature Publishing Group VL - 39 SP - 730 KW - chipchip KW - hnf4 KW - odom KW - young AU - Odom, Duncan AU - Dowell, Robin AU - Jacobsen, Elizabeth AU - Gordon, William AU - Danford, Timothy AU - MacIsaac, Kenzie AU - Rolfe, Alexander AU - Conboy, Caitlin AU - Gifford, David AU - Fraenkel, Ernest PY - 2007/06/21/ UR - http://dx.doi.org/10.1038/ng2047 ER -