Addressing parents' concerns: do multiple vaccines overwhelm or weaken the infant's immune system? Export

@article{citeulike:6083708, abstract = {Recent surveys found that an increasing number of parents are concerned that infants receive too many vaccines. Implicit in this concern is that the infant's immune system is inadequately developed to handle vaccines safely or that multiple vaccines may overwhelm the immune system. In this review, we will examine the following: 1) the ontogeny of the active immune response and the ability of neonates and young infants to respond to vaccines; 2) the theoretic capacity of an infant's immune system; 3) data that demonstrate that mild or moderate illness does not interfere with an infant's ability to generate protective immune responses to vaccines; 4) how infants respond to vaccines given in combination compared with the same vaccines given separately; 5) data showing that vaccinated children are not more likely to develop infections with other pathogens than unvaccinated children; and 6) the fact that infants actually encounter fewer antigens in vaccines today than they did 40 or 100 years ago.}, author = {Offit, Paul A. and Quarles, Jessica and Gerber, Michael A. and Hackett, Charles J. and Marcuse, Edgar K. and Kollman, Tobias R. and Gellin, Bruce G. and Landry, Sarah}, citeulike-article-id = {6083708}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11773551}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11773551}, comment = {Although we now give children more vaccines, the actual number of antigens they receive has declined. Whereas previously 1 vaccine, smallpox, contained about 200 proteins, now the 11 routinely recommended vaccines contain fewer than 130 proteins in total. Two factors account for this decline: first, the worldwide eradication of smallpox obviated the need for that vaccine, and second, advances in protein chemistry have resulted in vaccines containing fewer antigens (eg, replacement of whole-cell with acellular pertussis vaccine).}, issn = {1098-4275}, journal = {Pediatrics}, keywords = {sdn, vaccines}, month = {January}, number = {1}, pages = {124--129}, posted-at = {2009-11-08 07:31:56}, priority = {2}, title = {Addressing parents' concerns: do multiple vaccines overwhelm or weaken the infant's immune system?}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11773551}, volume = {109}, year = {2002} }

TY - JOUR ID - citeulike:6083708 L3 - citeulike-article-id:6083708 N2 - Recent surveys found that an increasing number of parents are concerned that infants receive too many vaccines. Implicit in this concern is that the infant's immune system is inadequately developed to handle vaccines safely or that multiple vaccines may overwhelm the immune system. In this review, we will examine the following: 1) the ontogeny of the active immune response and the ability of neonates and young infants to respond to vaccines; 2) the theoretic capacity of an infant's immune system; 3) data that demonstrate that mild or moderate illness does not interfere with an infant's ability to generate protective immune responses to vaccines; 4) how infants respond to vaccines given in combination compared with the same vaccines given separately; 5) data showing that vaccinated children are not more likely to develop infections with other pathogens than unvaccinated children; and 6) the fact that infants actually encounter fewer antigens in vaccines today than they did 40 or 100 years ago. IS - 1 JF - Pediatrics SN - 1098-4275 EP - 129 TI - Addressing parents' concerns: do multiple vaccines overwhelm or weaken the infant's immune system? VL - 109 SP - 124 KW - sdn KW - vaccines N1 - Although we now give children more vaccines, the actual number of antigens they receive has declined. Whereas previously 1 vaccine, smallpox, contained about 200 proteins, now the 11 routinely recommended vaccines contain fewer than 130 proteins in total. Two factors account for this decline: first, the worldwide eradication of smallpox obviated the need for that vaccine, and second, advances in protein chemistry have resulted in vaccines containing fewer antigens (eg, replacement of whole-cell with acellular pertussis vaccine). AU - Offit, Paul AU - Quarles, Jessica AU - Gerber, Michael AU - Hackett, Charles AU - Marcuse, Edgar AU - Kollman, Tobias AU - Gellin, Bruce AU - Landry, Sarah PY - 2002/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/11773551 ER -