Serotonin (5-HT) in veins: not all in vain. Export

@article{citeulike:3182996, abstract = {The circulatory system consists of veins and arteries. Compared with arteries, veins have been neglected in cardiovascular research. Although veins are significantly less muscular than similarly sized arteries, the contribution of veins to cardiovascular homeostasis cannot be left un-noted because veins accommodate 70\% of the circulating blood. Circulating blood platelets contain the majority of systemic 5-HT (5-hydroxytryptamine; serotonin). Similar to venous function, the physiological role of 5-HT in the cardiovascular system is not well understood. Here, we present not only a review on 5-HT and veins but ways in which these two topics might intersect in a physiologically relevant manner. Here we show the novel findings that veins exhibit higher amounts of intracellular 5-HT than arteries. Moreover, we also show evidence that, similar to arteries, veins have the ability to uptake 5-HT. In this review, we introduce the venous system as a reservoir for 5-HT in the periphery, suggesting that veins, in addition to arteries, may represent an important target for drugs that interfere with the serotonergic system. In addition, the serotonergic system from synthesis to metabolism, 5-HT receptor activation and venous diseases will also be discussed.}, address = {Department of Pharmacology and Toxicology, Michigan State University, B445 Life Sciences Building, East Lansing, MI 48824, USA. linderau@msu.edu}, author = {Linder, A. E. and Ni, W. and Diaz, J. L. and Szasz, T. and Burnett, R. and Watts, S. W.}, citeulike-article-id = {3182996}, citeulike-linkout-0 = {http://dx.doi.org/10.1124/jpet.107.122630}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17671100}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17671100}, doi = {10.1124/jpet.107.122630}, issn = {0022-3565}, journal = {The Journal of pharmacology and experimental therapeutics}, keywords = {cardiovascular, review, serotonin}, month = {November}, number = {2}, pages = {415--421}, posted-at = {2008-09-02 21:54:35}, priority = {4}, title = {Serotonin (5-HT) in veins: not all in vain.}, url = {http://dx.doi.org/10.1124/jpet.107.122630}, volume = {323}, year = {2007} }

TY - JOUR ID - citeulike:3182996 L3 - citeulike-article-id:3182996 N2 - The circulatory system consists of veins and arteries. Compared with arteries, veins have been neglected in cardiovascular research. Although veins are significantly less muscular than similarly sized arteries, the contribution of veins to cardiovascular homeostasis cannot be left un-noted because veins accommodate 70% of the circulating blood. Circulating blood platelets contain the majority of systemic 5-HT (5-hydroxytryptamine; serotonin). Similar to venous function, the physiological role of 5-HT in the cardiovascular system is not well understood. Here, we present not only a review on 5-HT and veins but ways in which these two topics might intersect in a physiologically relevant manner. Here we show the novel findings that veins exhibit higher amounts of intracellular 5-HT than arteries. Moreover, we also show evidence that, similar to arteries, veins have the ability to uptake 5-HT. In this review, we introduce the venous system as a reservoir for 5-HT in the periphery, suggesting that veins, in addition to arteries, may represent an important target for drugs that interfere with the serotonergic system. In addition, the serotonergic system from synthesis to metabolism, 5-HT receptor activation and venous diseases will also be discussed. IS - 2 JF - The Journal of pharmacology and experimental therapeutics SN - 0022-3565 AD - Department of Pharmacology and Toxicology, Michigan State University, B445 Life Sciences Building, East Lansing, MI 48824, USA. linderau@msu.edu EP - 421 TI - Serotonin (5-HT) in veins: not all in vain. VL - 323 SP - 415 KW - cardiovascular KW - review KW - serotonin AU - Linder, AE AU - Ni, W AU - Diaz, JL AU - Szasz, T AU - Burnett, R AU - Watts, SW PY - 2007/11// UR - http://dx.doi.org/10.1124/jpet.107.122630 ER -