Endogenous catecholamine synthesis, metabolism, storage and uptake in human neutrophils. Export

@article{citeulike:3183000, abstract = {Evidence is presented that human neutrophils contain catecholamines and several of their metabolites. In vitro, incubation with alpha-methyl-p-tyrosine or pargyline affects intracellular dopamine, norepinephrine and their metabolites, suggesting catecholamine synthesis and degradation by these cells. Reserpine reduces intracellular dopamine and norepinephrine and desipramine reduces intracellular norepinephrine, suggesting the presence of storage and uptake mechanism. In view of the ability of catecholamines to affect neutrophil function, the present results support the hypothesis that autoregulatory adrenergic mechanisms may exist in these cells.}, address = {Department of Internal Medicine and Therapeutics, University of Insubria, Varese, Italy.}, author = {Cosentino, M. and Marino, F. and Bombelli, R. and Ferrari, M. and Lecchini, S. and Frigo, G.}, citeulike-article-id = {3183000}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10201646}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10201646}, issn = {0024-3205}, journal = {Life sciences}, keywords = {dopamine, neutrophils, norepinephrine}, number = {11}, pages = {975--981}, posted-at = {2008-09-02 21:58:41}, priority = {3}, title = {Endogenous catecholamine synthesis, metabolism, storage and uptake in human neutrophils.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10201646}, volume = {64}, year = {1999} }

TY - JOUR ID - citeulike:3183000 L3 - citeulike-article-id:3183000 N2 - Evidence is presented that human neutrophils contain catecholamines and several of their metabolites. In vitro, incubation with alpha-methyl-p-tyrosine or pargyline affects intracellular dopamine, norepinephrine and their metabolites, suggesting catecholamine synthesis and degradation by these cells. Reserpine reduces intracellular dopamine and norepinephrine and desipramine reduces intracellular norepinephrine, suggesting the presence of storage and uptake mechanism. In view of the ability of catecholamines to affect neutrophil function, the present results support the hypothesis that autoregulatory adrenergic mechanisms may exist in these cells. IS - 11 JF - Life sciences SN - 0024-3205 AD - Department of Internal Medicine and Therapeutics, University of Insubria, Varese, Italy. EP - 981 TI - Endogenous catecholamine synthesis, metabolism, storage and uptake in human neutrophils. VL - 64 SP - 975 KW - dopamine KW - neutrophils KW - norepinephrine AU - Cosentino, M AU - Marino, F AU - Bombelli, R AU - Ferrari, M AU - Lecchini, S AU - Frigo, G PY - 1999/// UR - http://view.ncbi.nlm.nih.gov/pubmed/10201646 ER -