Structure-based virtual screening of chemical libraries for drug discovery. Export

@article{citeulike:778361, abstract = {One of the main goals in drug discovery is to identify new chemical entities that have a high likelihood of binding to the target protein to elicit the desired biological response. To this end, virtual screening is being increasingly used as a complement to high-throughput screening to improve the speed and efficiency of the drug discovery and development process. The availability of inexpensive high-performance computing platforms in recent years has transformed this field into one that is highly diverse and rapidly evolving, where large chemical databases have been successfully screened to identify hits for a wide range of targets such as Bcl-2 family proteins, G protein-coupled receptors, kinases, metalloproteins, nuclear hormone receptors, proteases and many more.}, address = {The Burnham Institute for Medical Research, La Jolla, CA 92037, USA.}, author = {Ghosh, S. and Nie, A. and An, J. and Huang, Z.}, citeulike-article-id = {778361}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cbpa.2006.04.002}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1367593106000536}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16675286}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16675286}, citeulike-linkout-4 = {http://www.sciencedirect.com/science/article/B6VRX-4JW15PF-1/2/9e61af7bf7eecc882513d84837d02923}, doi = {10.1016/j.cbpa.2006.04.002}, issn = {1367-5931}, journal = {Curr Opin Chem Biol}, keywords = {library, screening}, month = {June}, number = {3}, pages = {194--202}, posted-at = {2007-03-05 21:12:00}, priority = {3}, title = {Structure-based virtual screening of chemical libraries for drug discovery.}, url = {http://dx.doi.org/10.1016/j.cbpa.2006.04.002}, volume = {10}, year = {2006} }

TY - JOUR ID - citeulike:778361 L3 - citeulike-article-id:778361 N2 - One of the main goals in drug discovery is to identify new chemical entities that have a high likelihood of binding to the target protein to elicit the desired biological response. To this end, virtual screening is being increasingly used as a complement to high-throughput screening to improve the speed and efficiency of the drug discovery and development process. The availability of inexpensive high-performance computing platforms in recent years has transformed this field into one that is highly diverse and rapidly evolving, where large chemical databases have been successfully screened to identify hits for a wide range of targets such as Bcl-2 family proteins, G protein-coupled receptors, kinases, metalloproteins, nuclear hormone receptors, proteases and many more. IS - 3 JF - Curr Opin Chem Biol SN - 1367-5931 AD - The Burnham Institute for Medical Research, La Jolla, CA 92037, USA. EP - 202 TI - Structure-based virtual screening of chemical libraries for drug discovery. VL - 10 SP - 194 KW - library KW - screening AU - Ghosh, S AU - Nie, A AU - An, J AU - Huang, Z PY - 2006/06// UR - http://dx.doi.org/10.1016/j.cbpa.2006.04.002 ER -