Interhemispheric correlations of slow spontaneous neuronal fluctuations revealed in human sensory cortex. Export

@article{citeulike:3143040, abstract = {Animal studies have shown robust electrophysiological activity in the sensory cortex in the absence of stimuli or tasks. Similarly, recent human functional magnetic resonance imaging (fMRI) revealed widespread, spontaneously emerging cortical fluctuations. However, it is unknown what neuronal dynamics underlie this spontaneous activity in the human brain. Here we studied this issue by combining bilateral single-unit, local field potentials (LFPs) and intracranial electrocorticography (ECoG) recordings in individuals undergoing clinical monitoring. We found slow (<0.1 Hz, following 1/f-like profiles) spontaneous fluctuations of neuronal activity with significant interhemispheric correlations. These fluctuations were evident mainly in neuronal firing rates and in gamma (40-100 Hz) LFP power modulations. Notably, the interhemispheric correlations were enhanced during rapid eye movement and stage 2 sleep. Multiple intracranial ECoG recordings revealed clear selectivity for functional networks in the spontaneous gamma LFP power modulations. Our results point to slow spontaneous modulations in firing rate and gamma LFP as the likely correlates of spontaneous fMRI fluctuations in the human sensory cortex.}, address = {Department of Neurobiology, Weizmann Institute of Science, 240 Herzl Street, Rehovot 76100, Israel.}, author = {Nir, Yuval and Mukamel, Roy and Dinstein, Ilan and Privman, Eran and Harel, Michal and Fisch, Lior and Gelbard-Sagiv, Hagar and Kipervasser, Svetlana and Andelman, Fani and Neufeld, Miri Y Y. and Kramer, Uri and Arieli, Amos and Fried, Itzhak and Malach, Rafael}, citeulike-article-id = {3143040}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nn.2177}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nn.2177}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18711392}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18711392}, day = {24}, doi = {10.1038/nn.2177}, issn = {1546-1726}, journal = {Nature neuroscience}, keywords = {coherence, ecog, fmri, gamma, human, lfp, oscillation, rem, sleep, spontaneous}, month = {August}, posted-at = {2008-08-27 19:52:43}, priority = {2}, title = {Interhemispheric correlations of slow spontaneous neuronal fluctuations revealed in human sensory cortex.}, url = {http://dx.doi.org/10.1038/nn.2177}, year = {2008} }

TY - JOUR ID - citeulike:3143040 L3 - citeulike-article-id:3143040 N2 - Animal studies have shown robust electrophysiological activity in the sensory cortex in the absence of stimuli or tasks. Similarly, recent human functional magnetic resonance imaging (fMRI) revealed widespread, spontaneously emerging cortical fluctuations. However, it is unknown what neuronal dynamics underlie this spontaneous activity in the human brain. Here we studied this issue by combining bilateral single-unit, local field potentials (LFPs) and intracranial electrocorticography (ECoG) recordings in individuals undergoing clinical monitoring. We found slow (<0.1 Hz, following 1/f-like profiles) spontaneous fluctuations of neuronal activity with significant interhemispheric correlations. These fluctuations were evident mainly in neuronal firing rates and in gamma (40-100 Hz) LFP power modulations. Notably, the interhemispheric correlations were enhanced during rapid eye movement and stage 2 sleep. Multiple intracranial ECoG recordings revealed clear selectivity for functional networks in the spontaneous gamma LFP power modulations. Our results point to slow spontaneous modulations in firing rate and gamma LFP as the likely correlates of spontaneous fMRI fluctuations in the human sensory cortex. JF - Nature neuroscience SN - 1546-1726 AD - Department of Neurobiology, Weizmann Institute of Science, 240 Herzl Street, Rehovot 76100, Israel. TI - Interhemispheric correlations of slow spontaneous neuronal fluctuations revealed in human sensory cortex. KW - coherence KW - ecog KW - fmri KW - gamma KW - human KW - lfp KW - oscillation KW - rem KW - sleep KW - spontaneous AU - Nir, Yuval AU - Mukamel, Roy AU - Dinstein, Ilan AU - Privman, Eran AU - Harel, Michal AU - Fisch, Lior AU - Gelbard-Sagiv, Hagar AU - Kipervasser, Svetlana AU - Andelman, Fani AU - Neufeld, Miri Y AU - Kramer, Uri AU - Arieli, Amos AU - Fried, Itzhak AU - Malach, Rafael PY - 2008/08/24/ UR - http://dx.doi.org/10.1038/nn.2177 ER -