Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation Export

@article{citeulike:470149, abstract = {Microorganisms have been mutating and evolving on Earth for billions of years. Now, a field of research has developed around the idea of using microorganisms to study evolution in action. Controlled and replicated experiments are using viruses, bacteria and yeast to investigate how their genomes and phenotypic properties evolve over hundreds and even thousands of generations. Here, we examine the dynamics of evolutionary adaptation, the genetic bases of adaptation, tradeoffs and the environmental specificity of adaptation, the origin and evolutionary consequences of mutators, and the process of drift decay in very small populations.}, address = {Instituto de Biolog\'{\i}a Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cient\'{\i}ficas, 46022 Valencia, Spain. sfelena@ibmcp.upv.es}, author = {Elena, Santiago F. and Lenski, Richard E.}, citeulike-article-id = {470149}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg1088}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg1088}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/12776215}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=12776215}, day = {01}, doi = {10.1038/nrg1088}, issn = {1471-0056}, journal = {Nature Reviews Genetics}, keywords = {evolution}, month = {June}, number = {6}, pages = {457--469}, posted-at = {2009-10-15 08:58:04}, priority = {3}, publisher = {Nature Publishing Group}, title = {Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation}, url = {http://dx.doi.org/10.1038/nrg1088}, volume = {4}, year = {2003} }

TY - JOUR ID - citeulike:470149 L3 - citeulike-article-id:470149 N2 - Microorganisms have been mutating and evolving on Earth for billions of years. Now, a field of research has developed around the idea of using microorganisms to study evolution in action. Controlled and replicated experiments are using viruses, bacteria and yeast to investigate how their genomes and phenotypic properties evolve over hundreds and even thousands of generations. Here, we examine the dynamics of evolutionary adaptation, the genetic bases of adaptation, tradeoffs and the environmental specificity of adaptation, the origin and evolutionary consequences of mutators, and the process of drift decay in very small populations. IS - 6 JF - Nature Reviews Genetics SN - 1471-0056 AD - Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas, 46022 Valencia, Spain. sfelena@ibmcp.upv.es EP - 469 TI - Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation PB - Nature Publishing Group VL - 4 SP - 457 KW - evolution AU - Elena, Santiago AU - Lenski, Richard PY - 2003/06/01/ UR - http://dx.doi.org/10.1038/nrg1088 ER -