Specificity, free energy and information content in protein-DNA interactions Export

@article{citeulike:2711454, abstract = {Site-specific DNA-protein interactions can be studied using experimental and computational methods. Experimental approaches typically analyze a protein-DNA interaction by measuring the free energy of binding under a variety of conditions. Computational methods focus on alignments of known binding sites for a protein, and, from these alignments, make estimates of the binding energy. Understanding the relationship between these two perspectives, and finding ways to improve both, is a major challenge of modern molecular biology.}, author = {Stormo, Gary D. and Fields, Dana S.}, citeulike-article-id = {2711454}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0968-0004(98)01187-6}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0968-0004(98)01187-6}, citeulike-linkout-2 = {http://www.sciencedirect.com/science/article/B6TCV-3T6YHSH-9/1/93f06a8a584cae78f2021d2bb3c01c77}, day = {1}, doi = {10.1016/S0968-0004(98)01187-6}, journal = {Trends in Biochemical Sciences}, keywords = {binding, information}, month = {March}, number = {3}, pages = {109--113}, posted-at = {2008-05-26 10:53:20}, priority = {3}, title = {Specificity, free energy and information content in protein-DNA interactions}, url = {http://dx.doi.org/10.1016/S0968-0004(98)01187-6}, volume = {23}, year = {1998} }

TY - JOUR ID - citeulike:2711454 L3 - citeulike-article-id:2711454 N2 - Site-specific DNA-protein interactions can be studied using experimental and computational methods. Experimental approaches typically analyze a protein-DNA interaction by measuring the free energy of binding under a variety of conditions. Computational methods focus on alignments of known binding sites for a protein, and, from these alignments, make estimates of the binding energy. Understanding the relationship between these two perspectives, and finding ways to improve both, is a major challenge of modern molecular biology. IS - 3 JF - Trends in Biochemical Sciences EP - 113 TI - Specificity, free energy and information content in protein-DNA interactions VL - 23 SP - 109 KW - binding KW - information AU - Stormo, Gary AU - Fields, Dana PY - 1998/03/01/ UR - http://dx.doi.org/10.1016/S0968-0004(98)01187-6 ER -