Serum and intracellular magnesium deficiency in patients with metabolic syndrome--evidences for its relation to insulin resistance. Export

@article{citeulike:3908494, abstract = {This cross sectional study evaluated serum (SMg) and intramononuclear (MMg) magnesium in patients with metabolic syndrome without diabetes and correlated them with cardiovascular risk factors. 72 patients and 57 controls (blood donors) were studied. Hypomagnesemia (SMg<1.7 mg/dL) was seen in 23.2\% and intracellular depletion in 36.1\% of the patients. SMg and MMg means were significantly lower in patients than in controls: 1.80+/-0.18 mg/dL vs. 2.43+/-0.43 mg/dL and 0.98+/-0.55 microg/mg vs. 1.67+/-0.64 microg/mg of protein (P<0.001). Inverse correlation was observed between, SMg and MMg with BMI; SMg with systolic blood pressure and waist circumference in women. Patients with acanthosis nigricans had lower SMg (1.75+/-0.18 mg/dL vs. 1.85+/- 0.18 mg/dL, P<0.05). Non-white people had lower SMg (1.78+/-0.16 mg/dL vs. 1.92+/-0.24 mg/dL, P=0.007) and MMg (0.95+/-0.59 microg/mg vs. 1.13+/-0.42 microg/mg, P=0.03). Patients with IR showed lower MgM means (0.84+/-0.33 microg/mg vs. 1.14+/-0.69 microg/mg, P<0.05). The same occurred in patients with low HDL-c levels (0.92+/-0.46 microg/mg vs. 1.20+/-0.70 microg/mg, P=0.03), and those with moderate and severe hepatic steatosis (0.77+/-0.29 microg/mg vs. 1.21+/-0.80 microg/mg, P<0.05). In conclusion, magnesium depletion in serum and mononuclear cells is common in obese people with metabolic syndrome, and it is more evident in non-white people with insulin resistance. This depletion may contribute to a post-receptor insulin resistance.}, author = {Lima, Maria de Lourdes d. e. . L. and Cruz, Thomaz and Rodrigues, Luiz Erlon E. and Bomfim, Ol\'{\i}via and Melo, Juliana and Correia, Raquel and Porto, Mirna and Cedro, Alexandre and Vicente, Eli\'{e}zer}, citeulike-article-id = {3908494}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.diabres.2008.11.019}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19124169}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19124169}, day = {3}, doi = {10.1016/j.diabres.2008.11.019}, issn = {1872-8227}, journal = {Diabetes research and clinical practice}, keywords = {magnesium, metabolic-syndrome}, month = {February}, number = {2}, pages = {257--262}, posted-at = {2009-10-26 23:57:36}, priority = {2}, title = {Serum and intracellular magnesium deficiency in patients with metabolic syndrome--evidences for its relation to insulin resistance.}, url = {http://dx.doi.org/10.1016/j.diabres.2008.11.019}, volume = {83}, year = {2009} }

TY - JOUR ID - citeulike:3908494 L3 - citeulike-article-id:3908494 N2 - This cross sectional study evaluated serum (SMg) and intramononuclear (MMg) magnesium in patients with metabolic syndrome without diabetes and correlated them with cardiovascular risk factors. 72 patients and 57 controls (blood donors) were studied. Hypomagnesemia (SMg<1.7 mg/dL) was seen in 23.2% and intracellular depletion in 36.1% of the patients. SMg and MMg means were significantly lower in patients than in controls: 1.80+/-0.18 mg/dL vs. 2.43+/-0.43 mg/dL and 0.98+/-0.55 microg/mg vs. 1.67+/-0.64 microg/mg of protein (P<0.001). Inverse correlation was observed between, SMg and MMg with BMI; SMg with systolic blood pressure and waist circumference in women. Patients with acanthosis nigricans had lower SMg (1.75+/-0.18 mg/dL vs. 1.85+/- 0.18 mg/dL, P<0.05). Non-white people had lower SMg (1.78+/-0.16 mg/dL vs. 1.92+/-0.24 mg/dL, P=0.007) and MMg (0.95+/-0.59 microg/mg vs. 1.13+/-0.42 microg/mg, P=0.03). Patients with IR showed lower MgM means (0.84+/-0.33 microg/mg vs. 1.14+/-0.69 microg/mg, P<0.05). The same occurred in patients with low HDL-c levels (0.92+/-0.46 microg/mg vs. 1.20+/-0.70 microg/mg, P=0.03), and those with moderate and severe hepatic steatosis (0.77+/-0.29 microg/mg vs. 1.21+/-0.80 microg/mg, P<0.05). In conclusion, magnesium depletion in serum and mononuclear cells is common in obese people with metabolic syndrome, and it is more evident in non-white people with insulin resistance. This depletion may contribute to a post-receptor insulin resistance. IS - 2 JF - Diabetes research and clinical practice SN - 1872-8227 EP - 262 TI - Serum and intracellular magnesium deficiency in patients with metabolic syndrome--evidences for its relation to insulin resistance. VL - 83 SP - 257 KW - magnesium KW - metabolic-syndrome AU - Lima, Maria de Lourdes AU - Cruz, Thomaz AU - Rodrigues, Luiz Erlon AU - Bomfim, Olívia AU - Melo, Juliana AU - Correia, Raquel AU - Porto, Mirna AU - Cedro, Alexandre AU - Vicente, Eliézer PY - 2009/02/03/ UR - http://dx.doi.org/10.1016/j.diabres.2008.11.019 ER -