Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine Export

@article{citeulike:5848128, abstract = {Background: The effects of food restriction on energy metabolism have been under investigation for more than a century. Data obtained are conflicting and research has failed to provide conclusive results. Objective: The objective of this study was to test the hypothesis that in lean subjects under normal living conditions, short-term starvation leads to an increase in serum concentrations of catecholamines and thus to an increase in resting energy expenditure. Design: Resting energy expenditure, measured by indirect calorimetry, and hormone and substrate concentrations were measured in 11 healthy, lean subjects on days 1, 2, 3, and 4 of an 84-h starvation period. Results: Resting energy expenditure increased significantly from 3.97 {+/-} 0.9 kJ/min on day 1 to 4.53 {+/-} 0.9 kJ/min on day 3 (P < 0.05). The increase in resting energy expenditure was associated with an increase in the norepinephrine concentration from 1716. {+/-} 574 pmol/L on day 1 to 3728 {+/-} 1636 pmol/L on day 4 (P < 0.05). Serum glucose decreased from 4.9 {+/-} 0.5 to 3.5 {+/-} 0.5 mmol/L (P < 0.05), whereas insulin did not change significantly. Conclusions: Resting energy expenditure increases in early starvation, accompanied by an increase in plasma norepinephrine. This increase in norepinephrine seems to be due to a decline in serum glucose and may be the initial signal for metabolic changes in early starvation.}, author = {Zauner, Christian and Schneeweiss, Bruno and Kranz, Alexander and Madl, Christian and Ratheiser, Klaus and Kramer, Ludwig and Roth, Erich and Schneider, Barbara and Lenz, Kurt}, citeulike-article-id = {5848128}, citeulike-linkout-0 = {http://www.ajcn.org/content/71/6/1511.abstract}, citeulike-linkout-1 = {http://www.ajcn.org/content/71/6/1511.full.pdf}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/10837292}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=10837292}, day = {1}, journal = {Am J Clin Nutr}, keywords = {fasting, metabolism, norepinephrine}, month = {June}, number = {6}, pages = {1511--1515}, posted-at = {2009-09-29 06:40:33}, priority = {2}, title = {Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine}, url = {http://www.ajcn.org/content/71/6/1511.abstract}, volume = {71}, year = {2000} }

TY - JOUR ID - citeulike:5848128 L3 - citeulike-article-id:5848128 N2 - Background: The effects of food restriction on energy metabolism have been under investigation for more than a century. Data obtained are conflicting and research has failed to provide conclusive results. Objective: The objective of this study was to test the hypothesis that in lean subjects under normal living conditions, short-term starvation leads to an increase in serum concentrations of catecholamines and thus to an increase in resting energy expenditure. Design: Resting energy expenditure, measured by indirect calorimetry, and hormone and substrate concentrations were measured in 11 healthy, lean subjects on days 1, 2, 3, and 4 of an 84-h starvation period. Results: Resting energy expenditure increased significantly from 3.97 {+/-} 0.9 kJ/min on day 1 to 4.53 {+/-} 0.9 kJ/min on day 3 (P < 0.05). The increase in resting energy expenditure was associated with an increase in the norepinephrine concentration from 1716. {+/-} 574 pmol/L on day 1 to 3728 {+/-} 1636 pmol/L on day 4 (P < 0.05). Serum glucose decreased from 4.9 {+/-} 0.5 to 3.5 {+/-} 0.5 mmol/L (P < 0.05), whereas insulin did not change significantly. Conclusions: Resting energy expenditure increases in early starvation, accompanied by an increase in plasma norepinephrine. This increase in norepinephrine seems to be due to a decline in serum glucose and may be the initial signal for metabolic changes in early starvation. IS - 6 JF - Am J Clin Nutr EP - 1515 TI - Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine VL - 71 SP - 1511 KW - fasting KW - metabolism KW - norepinephrine AU - Zauner, Christian AU - Schneeweiss, Bruno AU - Kranz, Alexander AU - Madl, Christian AU - Ratheiser, Klaus AU - Kramer, Ludwig AU - Roth, Erich AU - Schneider, Barbara AU - Lenz, Kurt PY - 2000/06/01/ UR - http://www.ajcn.org/content/71/6/1511.abstract ER -