Gene Family Evolution across 12 Drosophila Genomes Export

@article{citeulike:1891097, abstract = {Author SummaryThough comparative genome sequencing has revealed vast similarities in the total number of genes contained within closely related species, this similarity hides enormous complexities in the identity and number of constituent proteins. Species can differ in their complement of genes through both gene duplication and loss. Here we investigated the gain and loss of genes from the genomes of 12 fully sequenced Drosophila (fruit flies). We find high rates of gain and loss in all species and estimate that approximately one new gene is gained or lost every 60,000 years. We also find several hundred cases of extremely rapid gene turnover, with dozens of genes gained or lost in only a few million years. The highest turnover in gene number occurs in genes involved in sex and reproduction. Taken together, our results demonstrate that the apparent stasis in total gene number among species has masked rapid turnover in individual gene gain and loss. It is likely that this evolutionary revolving door has played a large role in shaping the morphological, physiological, and metabolic differences among species.}, author = {Hahn, Matthew W. and Han, Mira V. and Han, Sang-Gook}, citeulike-article-id = {1891097}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pgen.0030197}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17997610}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17997610}, day = {9}, doi = {10.1371/journal.pgen.0030197}, journal = {PLoS Genet}, keywords = {drosophila, gene-duplication, spermatogenesis}, month = {November}, number = {11}, pages = {e197+}, posted-at = {2008-10-28 19:02:20}, priority = {2}, publisher = {Public Library of Science}, title = {Gene Family Evolution across 12 Drosophila Genomes}, url = {http://dx.doi.org/10.1371/journal.pgen.0030197}, volume = {3}, year = {2007} }

TY - JOUR ID - citeulike:1891097 L3 - citeulike-article-id:1891097 N2 - Author SummaryThough comparative genome sequencing has revealed vast similarities in the total number of genes contained within closely related species, this similarity hides enormous complexities in the identity and number of constituent proteins. Species can differ in their complement of genes through both gene duplication and loss. Here we investigated the gain and loss of genes from the genomes of 12 fully sequenced Drosophila (fruit flies). We find high rates of gain and loss in all species and estimate that approximately one new gene is gained or lost every 60,000 years. We also find several hundred cases of extremely rapid gene turnover, with dozens of genes gained or lost in only a few million years. The highest turnover in gene number occurs in genes involved in sex and reproduction. Taken together, our results demonstrate that the apparent stasis in total gene number among species has masked rapid turnover in individual gene gain and loss. It is likely that this evolutionary revolving door has played a large role in shaping the morphological, physiological, and metabolic differences among species. IS - 11 JF - PLoS Genet TI - Gene Family Evolution across 12 Drosophila Genomes PB - Public Library of Science VL - 3 SP - e197 KW - drosophila KW - gene-duplication KW - spermatogenesis AU - Hahn, Matthew AU - Han, Mira AU - Han, Sang-Gook PY - 2007/11/09/ UR - http://dx.doi.org/10.1371/journal.pgen.0030197 ER -