SirT1 regulates energy metabolism and response to caloric restriction in mice. Export

@article{citeulike:2626083, abstract = {The yeast sir2 gene and its orthologues in Drosophila and C. elegans have well-established roles in lifespan determination and response to caloric restriction. We have studied mice carrying two null alleles for SirT1, the mammalian orthologue of sir2, and found that these animals inefficiently utilize ingested food. These mice are hypermetabolic, contain inefficient liver mitochondria, and have elevated rates of lipid oxidation. When challenged with a 40\% reduction in caloric intake, normal mice maintained their metabolic rate and increased their physical activity while the metabolic rate of SirT1-null mice dropped and their activity did not increase. Moreover, CR did not extend lifespan of SirT1-null mice. Thus, SirT1 is an important regulator of energy metabolism and, like its orthologues from simpler eukaryotes, the SirT1 protein appears to be required for a normal response to caloric restriction.}, address = {Center for Cancer Therapeutics, Ottawa Health Research Institute, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.}, author = {Boily, G. and Seifert, E. L. and Bevilacqua, L. and He, X. H. and Sabourin, G. and Estey, C. and Moffat, C. and Crawford, S. and Saliba, S. and Jardine, K. and Xuan, J. and Evans, M. and Harper, M. E. and McBurney, M. W.}, citeulike-article-id = {2626083}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pone.0001759}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18335035}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18335035}, doi = {10.1371/journal.pone.0001759}, issn = {1932-6203}, journal = {PLoS ONE}, keywords = {cr, sirt1}, number = {3}, posted-at = {2008-04-03 14:39:36}, priority = {2}, title = {SirT1 regulates energy metabolism and response to caloric restriction in mice.}, url = {http://dx.doi.org/10.1371/journal.pone.0001759}, volume = {3}, year = {2008} }

TY - JOUR ID - citeulike:2626083 L3 - citeulike-article-id:2626083 N2 - The yeast sir2 gene and its orthologues in Drosophila and C. elegans have well-established roles in lifespan determination and response to caloric restriction. We have studied mice carrying two null alleles for SirT1, the mammalian orthologue of sir2, and found that these animals inefficiently utilize ingested food. These mice are hypermetabolic, contain inefficient liver mitochondria, and have elevated rates of lipid oxidation. When challenged with a 40% reduction in caloric intake, normal mice maintained their metabolic rate and increased their physical activity while the metabolic rate of SirT1-null mice dropped and their activity did not increase. Moreover, CR did not extend lifespan of SirT1-null mice. Thus, SirT1 is an important regulator of energy metabolism and, like its orthologues from simpler eukaryotes, the SirT1 protein appears to be required for a normal response to caloric restriction. IS - 3 JF - PLoS ONE SN - 1932-6203 AD - Center for Cancer Therapeutics, Ottawa Health Research Institute, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada. TI - SirT1 regulates energy metabolism and response to caloric restriction in mice. VL - 3 KW - cr KW - sirt1 AU - Boily, G AU - Seifert, EL AU - Bevilacqua, L AU - He, XH AU - Sabourin, G AU - Estey, C AU - Moffat, C AU - Crawford, S AU - Saliba, S AU - Jardine, K AU - Xuan, J AU - Evans, M AU - Harper, ME AU - McBurney, MW PY - 2008/// UR - http://dx.doi.org/10.1371/journal.pone.0001759 ER -