Sir2 and calorie restriction in yeast: A skeptical perspective Export

@article{citeulike:2626086, abstract = {Activation of Sir2-family proteins in response to calorie restriction (CR) has been proposed as an evolutionarily conserved mechanism for life span extension. This idea has been called into question with the discovery that Sir2-family proteins are not required for life span extension from CR in yeast. We present here a historical perspective and critical evaluation of the model that CR acts through Sir2 in yeast, and interpret prior reports in light of more recent discoveries. Several specific cases where the Sir2 model of CR is inconsistent with experimental data are noted. These shortcomings must be considered along with evidence supporting a role for Sir2 in CR in order to fully evaluate the validity of this model.}, author = {Kaeberlein, Matt and Powers}, citeulike-article-id = {2626086}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.arr.2007.04.001}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17512264}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17512264}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6X1H-4NJ0TC9-1/2/94e60c9a32bfcec5c757faee61eb9dda}, doi = {10.1016/j.arr.2007.04.001}, journal = {Ageing Research Reviews}, keywords = {calorie-restriction, cr, sir2, yeast}, month = {August}, number = {2}, pages = {128--140}, posted-at = {2008-04-03 14:52:49}, priority = {2}, title = {Sir2 and calorie restriction in yeast: A skeptical perspective}, url = {http://dx.doi.org/10.1016/j.arr.2007.04.001}, volume = {6}, year = {2007} }

TY - JOUR ID - citeulike:2626086 L3 - citeulike-article-id:2626086 N2 - Activation of Sir2-family proteins in response to calorie restriction (CR) has been proposed as an evolutionarily conserved mechanism for life span extension. This idea has been called into question with the discovery that Sir2-family proteins are not required for life span extension from CR in yeast. We present here a historical perspective and critical evaluation of the model that CR acts through Sir2 in yeast, and interpret prior reports in light of more recent discoveries. Several specific cases where the Sir2 model of CR is inconsistent with experimental data are noted. These shortcomings must be considered along with evidence supporting a role for Sir2 in CR in order to fully evaluate the validity of this model. IS - 2 JF - Ageing Research Reviews EP - 140 TI - Sir2 and calorie restriction in yeast: A skeptical perspective VL - 6 SP - 128 KW - calorie-restriction KW - cr KW - sir2 KW - yeast AU - Kaeberlein, Matt AU - Powers PY - 2007/08// UR - http://dx.doi.org/10.1016/j.arr.2007.04.001 ER -