Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation Export

@article{citeulike:4607275, abstract = {In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed "the Warburg effect." Aerobic glycolysis is an inefficient way to generate adenosine 5'-triphosphate (ATP), however, and the advantage it confers to cancer cells has been unclear. Here we propose that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass (e.g., nucleotides, amino acids, and lipids) needed to produce a new cell. Supporting this idea are recent studies showing that (i) several signaling pathways implicated in cell proliferation also regulate metabolic pathways that incorporate nutrients into biomass; and that (ii) certain cancer-associated mutations enable cancer cells to acquire and metabolize nutrients in a manner conducive to proliferation rather than efficient ATP production. A better understanding of the mechanistic links between cellular metabolism and growth control may ultimately lead to better treatments for human cancer. 10.1126/science.1160809}, author = {Vander and Cantley, Lewis C. and Thompson, Craig B.}, citeulike-article-id = {4607275}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1160809}, citeulike-linkout-1 = {http://www.sciencemag.org/content/324/5930/1029.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/324/5930/1029.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/324/5930/1029?sa_campaign=Email}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/19460998}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=19460998}, day = {22}, doi = {10.1126/science.1160809}, issn = {1095-9203}, journal = {Science}, keywords = {cancer, glucose, metabolism, review}, month = {May}, number = {5930}, pages = {1029--1033}, posted-at = {2009-05-28 21:57:30}, priority = {2}, title = {Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation}, url = {http://dx.doi.org/10.1126/science.1160809}, volume = {324}, year = {2009} }

TY - JOUR ID - citeulike:4607275 L3 - citeulike-article-id:4607275 N2 - In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed "the Warburg effect." Aerobic glycolysis is an inefficient way to generate adenosine 5'-triphosphate (ATP), however, and the advantage it confers to cancer cells has been unclear. Here we propose that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass (e.g., nucleotides, amino acids, and lipids) needed to produce a new cell. Supporting this idea are recent studies showing that (i) several signaling pathways implicated in cell proliferation also regulate metabolic pathways that incorporate nutrients into biomass; and that (ii) certain cancer-associated mutations enable cancer cells to acquire and metabolize nutrients in a manner conducive to proliferation rather than efficient ATP production. A better understanding of the mechanistic links between cellular metabolism and growth control may ultimately lead to better treatments for human cancer. 10.1126/science.1160809 IS - 5930 JF - Science SN - 1095-9203 EP - 1033 TI - Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation VL - 324 SP - 1029 KW - cancer KW - glucose KW - metabolism KW - review AU - Vander AU - Cantley, Lewis AU - Thompson, Craig PY - 2009/05/22/ UR - http://dx.doi.org/10.1126/science.1160809 ER -