Proteasome inhibitors: valuable new tools for cell biologists. Export

@article{citeulike:97120, abstract = {Proteasomes are major sites for protein degradation in eukaryotic cells. The recent identification of selective proteasome inhibitors has allowed a definition of the roles of the ubiquitin-proteasome pathway in various cellular processes, such as antigen presentation and the degradation of regulatory or membrane proteins. This review describes the actions of these inhibitors, how they can be used to investigate cellular responses, the functions of the proteasome demonstrated by such studies and their potential applications in the future.}, address = {Dept of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.}, author = {Lee, D. H. and Goldberg, A. L.}, citeulike-article-id = {97120}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9789328}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9789328}, issn = {0962-8924}, journal = {Trends Cell Biol}, keywords = {inhibitor, proteasome}, month = {October}, number = {10}, pages = {397--403}, posted-at = {2007-04-22 04:43:04}, priority = {2}, title = {Proteasome inhibitors: valuable new tools for cell biologists.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9789328}, volume = {8}, year = {1998} }

TY - JOUR ID - citeulike:97120 L3 - citeulike-article-id:97120 N2 - Proteasomes are major sites for protein degradation in eukaryotic cells. The recent identification of selective proteasome inhibitors has allowed a definition of the roles of the ubiquitin-proteasome pathway in various cellular processes, such as antigen presentation and the degradation of regulatory or membrane proteins. This review describes the actions of these inhibitors, how they can be used to investigate cellular responses, the functions of the proteasome demonstrated by such studies and their potential applications in the future. IS - 10 JF - Trends Cell Biol SN - 0962-8924 AD - Dept of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. EP - 403 TI - Proteasome inhibitors: valuable new tools for cell biologists. VL - 8 SP - 397 KW - inhibitor KW - proteasome AU - Lee, DH AU - Goldberg, AL PY - 1998/10// UR - http://view.ncbi.nlm.nih.gov/pubmed/9789328 ER -