bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila

by: Julius Brennecke, David R Hipfner, Alexander Stark, Robert B Russell, Stephen M Cohen

Cell, Vol. 113, No. 1. (4 April 2003), pp. 25-36.

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Abstract

Cell proliferation, cell death, and pattern formation are coordinated in animal development. Although many proteins that control cell proliferation and apoptosis have been identified, the means by which these effectors are linked to the patterning machinery remain poorly understood. Here, we report that the bantam gene of Drosophila encodes a 21 nucleotide microRNA that promotes tissue growth. bantam expression is temporally and spatially regulated in response to patterning cues. bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity.

@article{citeulike:2191609, abstract = {Cell proliferation, cell death, and pattern formation are coordinated in animal development. Although many proteins that control cell proliferation and apoptosis have been identified, the means by which these effectors are linked to the patterning machinery remain poorly understood. Here, we report that the bantam gene of Drosophila encodes a 21 nucleotide microRNA that promotes tissue growth. bantam expression is temporally and spatially regulated in response to patterning cues. bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity.}, author = {Brennecke, Julius and Hipfner, David R. and Stark, Alexander and Russell, Robert B. and Cohen, Stephen M. }, citeulike-article-id = {2191609}, doi = {10.1016/S0092-8674(03)00231-9}, journal = {Cell}, keywords = {drosophila, mirna, neuron, rnai, trafficking}, month = {April}, number = {1}, pages = {25--36}, posted-at = {2008-01-03 15:12:01}, priority = {0}, title = {bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila}, url = {http://dx.doi.org/10.1016/S0092-8674(03)00231-9}, volume = {113}, year = {2003} }

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TY - JOUR ID - citeulike:2191609 L3 - citeulike-article-id:2191609 TI - bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila JF - Cell VL - 113 IS - 1 SP - 25 EP - 36 N2 - Cell proliferation, cell death, and pattern formation are coordinated in animal development. Although many proteins that control cell proliferation and apoptosis have been identified, the means by which these effectors are linked to the patterning machinery remain poorly understood. Here, we report that the bantam gene of Drosophila encodes a 21 nucleotide microRNA that promotes tissue growth. bantam expression is temporally and spatially regulated in response to patterning cues. bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity. KW - drosophila KW - mirna KW - neuron KW - rnai KW - trafficking AU - Brennecke, Julius AU - Hipfner, David AU - Stark, Alexander AU - Russell, Robert AU - Cohen, Stephen PY - 2003/04/04/ UR - http://dx.doi.org/10.1016/S0092-8674(03)00231-9 ER -

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