Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Which Are Also Selectively and Powerfully Cytotoxic to Cancer Cells Export

@article{Rosenthal09, abstract = {A new series of 6 dimeric trioxane sulfones has been prepared from the natural trioxane artemisinin in five or six chemical steps. One of these thermally and hydrolytically stable new chemical entities (4c) completely cured malaria-infected mice via a single oral dose of 144 mg/kg. At a much lower single oral dose of only 54 mg/kg combined with 13 mg/kg of mefloquine hydrochloride, this trioxane dimer 4c as well as its parent trioxane dimer 4b also completely cured malaria-infected mice. Both dimers 4c and 4b were potently and selectively cytotoxic toward five cancer cell lines.}, author = {Rosenthal, Andrew S. and Chen, Xiaochun and Liu, Jun O. and West, Diana C. and Hergenrother, Paul J. and Shapiro, Theresa A. and Posner, Gary H.}, citeulike-article-id = {4324850}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/jm801484v}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/jm801484v}, day = {26}, doi = {10.1021/jm801484v}, journal = {Journal of Medicinal Chemistry}, keywords = {artemisinin, dimeric, malaria, sulfones, trioxane}, month = {February}, number = {4}, pages = {1198--1203}, posted-at = {2009-04-16 07:59:19}, priority = {2}, title = {Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Which Are Also Selectively and Powerfully Cytotoxic to Cancer Cells}, url = {http://dx.doi.org/10.1021/jm801484v}, volume = {52}, year = {2009} }

TY - JOUR ID - Rosenthal09 L3 - citeulike-article-id:4324850 N2 - A new series of 6 dimeric trioxane sulfones has been prepared from the natural trioxane artemisinin in five or six chemical steps. One of these thermally and hydrolytically stable new chemical entities (4c) completely cured malaria-infected mice via a single oral dose of 144 mg/kg. At a much lower single oral dose of only 54 mg/kg combined with 13 mg/kg of mefloquine hydrochloride, this trioxane dimer 4c as well as its parent trioxane dimer 4b also completely cured malaria-infected mice. Both dimers 4c and 4b were potently and selectively cytotoxic toward five cancer cell lines. IS - 4 JF - Journal of Medicinal Chemistry EP - 1203 TI - Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Which Are Also Selectively and Powerfully Cytotoxic to Cancer Cells VL - 52 SP - 1198 KW - artemisinin KW - dimeric KW - malaria KW - sulfones KW - trioxane AU - Rosenthal, Andrew AU - Chen, Xiaochun AU - Liu, Jun AU - West, Diana AU - Hergenrother, Paul AU - Shapiro, Theresa AU - Posner, Gary PY - 2009/02/26/ UR - http://dx.doi.org/10.1021/jm801484v ER -