Gene Expression in Kidney Cancer Is Associated with Cytogenetic Abnormalities, Metastasis Formation, and Patient Survival Export

@article{citeulike:5942885, abstract = {Current diagnosis of renal cancer consists of histopathologic examination of tissue sections and classification into tumor stages and grades of malignancy. Until recently, molecular differences between tumor types were largely unknown. To examine such differences, we did gene expression measurements of 112 renal cell carcinoma and normal kidney samples on renal cell carcinoma\^{a}€“specific cDNA microarrays containing 4,207 genes and expressed sequence tags. The gene expression patterns showed deregulation of complete biological pathways in the tumors. Many of the molecular changes corresponded well to the histopathologic tumor types, and a set of 80 genes was sufficient to classify tumors with a very low error rate. Distinct gene expression signatures were associated with chromosomal abnormalities of tumor cells, metastasis formation, and patient survival. The data highlight the benefit of microarrays to detect novel tumor classes and to identify genes that are associated with patient variables and tumor properties.}, author = {S\~{A}¼ltmann, Holger and Heydebreck, Anja and Huber, Wolfgang and Kuner, Ruprecht and Bune\^{I}², Andreas and Vogt, Markus and Gunawan, Bastian and Vingron, Martin and F\~{A}¼zes\~{A}­, Laszlo and Poustka, Annemarie}, citeulike-article-id = {5942885}, citeulike-linkout-0 = {http://clincancerres.aacrjournals.org/content/11/2/646.abstract}, citeulike-linkout-1 = {http://clincancerres.aacrjournals.org/content/11/2/646.full.pdf}, day = {15}, journal = {Clinical Cancer Research}, keywords = {genectics, molecular, renal\_cell\_carcinoma}, month = {January}, number = {2}, pages = {646--655}, posted-at = {2009-10-15 10:29:19}, priority = {2}, title = {Gene Expression in Kidney Cancer Is Associated with Cytogenetic Abnormalities, Metastasis Formation, and Patient Survival}, url = {http://clincancerres.aacrjournals.org/content/11/2/646.abstract}, volume = {11}, year = {2005} }

TY - JOUR ID - citeulike:5942885 L3 - citeulike-article-id:5942885 N2 - Current diagnosis of renal cancer consists of histopathologic examination of tissue sections and classification into tumor stages and grades of malignancy. Until recently, molecular differences between tumor types were largely unknown. To examine such differences, we did gene expression measurements of 112 renal cell carcinoma and normal kidney samples on renal cell carcinoma–specific cDNA microarrays containing 4,207 genes and expressed sequence tags. The gene expression patterns showed deregulation of complete biological pathways in the tumors. Many of the molecular changes corresponded well to the histopathologic tumor types, and a set of 80 genes was sufficient to classify tumors with a very low error rate. Distinct gene expression signatures were associated with chromosomal abnormalities of tumor cells, metastasis formation, and patient survival. The data highlight the benefit of microarrays to detect novel tumor classes and to identify genes that are associated with patient variables and tumor properties. IS - 2 JF - Clinical Cancer Research EP - 655 TI - Gene Expression in Kidney Cancer Is Associated with Cytogenetic Abnormalities, Metastasis Formation, and Patient Survival VL - 11 SP - 646 KW - genectics KW - molecular KW - renal_cell_carcinoma AU - Sültmann, Holger AU - Heydebreck, Anja AU - Huber, Wolfgang AU - Kuner, Ruprecht AU - Buneβ, Andreas AU - Vogt, Markus AU - Gunawan, Bastian AU - Vingron, Martin AU - Füzesí, Laszlo AU - Poustka, Annemarie PY - 2005/01/15/ UR - http://clincancerres.aacrjournals.org/content/11/2/646.abstract ER -