Trimeric G protein-dependent frizzled signaling in Drosophila. Export

@article{citeulike:351784, abstract = {Frizzled (Fz) proteins are serpentine receptors that transduce critical cellular signals during development. Serpentine receptors usually signal to downstream effectors through an associated trimeric G protein complex. However, clear evidence for the role of trimeric G protein complexes for the Fz family of receptors has hitherto been lacking. Here, we show roles for the Galpha(o) subunit (Go) in mediating the two distinct pathways transduced by Fz receptors in Drosophila: the Wnt and planar polarity pathways. Go is required for transduction of both pathways, and epistasis experiments suggest that it is an immediate transducer of Fz. While overexpression effects of the wild-type form are receptor dependent, the activated form (Go-GTP) can signal when the receptor is removed. Thus, Go is likely part of a trimeric G protein complex that directly transduces Fz signals from the membrane to downstream components.}, address = {Department of Genetics and Development, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 701 West 168 Street, New York, NY 10032, USA.}, author = {Katanaev, V. L. and Ponzielli, R. and S\'{e}m\'{e}riva, M. and Tomlinson, A.}, citeulike-article-id = {351784}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2004.11.014}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15652486}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15652486}, day = {14}, doi = {10.1016/j.cell.2004.11.014}, issn = {0092-8674}, journal = {Cell}, keywords = {frizzled, g, proteins, wnt}, month = {January}, number = {1}, pages = {111--122}, posted-at = {2005-10-15 23:50:50}, priority = {2}, title = {Trimeric G protein-dependent frizzled signaling in Drosophila.}, url = {http://dx.doi.org/10.1016/j.cell.2004.11.014}, volume = {120}, year = {2005} }

TY - JOUR ID - citeulike:351784 L3 - citeulike-article-id:351784 N2 - Frizzled (Fz) proteins are serpentine receptors that transduce critical cellular signals during development. Serpentine receptors usually signal to downstream effectors through an associated trimeric G protein complex. However, clear evidence for the role of trimeric G protein complexes for the Fz family of receptors has hitherto been lacking. Here, we show roles for the Galpha(o) subunit (Go) in mediating the two distinct pathways transduced by Fz receptors in Drosophila: the Wnt and planar polarity pathways. Go is required for transduction of both pathways, and epistasis experiments suggest that it is an immediate transducer of Fz. While overexpression effects of the wild-type form are receptor dependent, the activated form (Go-GTP) can signal when the receptor is removed. Thus, Go is likely part of a trimeric G protein complex that directly transduces Fz signals from the membrane to downstream components. IS - 1 JF - Cell SN - 0092-8674 AD - Department of Genetics and Development, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 701 West 168 Street, New York, NY 10032, USA. EP - 122 TI - Trimeric G protein-dependent frizzled signaling in Drosophila. VL - 120 SP - 111 KW - frizzled KW - g KW - proteins KW - wnt AU - Katanaev, VL AU - Ponzielli, R AU - Sémériva, M AU - Tomlinson, A PY - 2005/01/14/ UR - http://dx.doi.org/10.1016/j.cell.2004.11.014 ER -