Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. Export

@article{citeulike:353325, abstract = {Signaling through tyrosine kinase receptors (TKRs) is thought to be modulated by receptor-mediated endocytosis and degradation of the receptor in the lysosome. However, factors that regulate endosomal sorting of TKRs are largely unknown. Here, we demonstrate that Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) is one such factor. Electron microscopy studies of hrs mutant larvae reveal an impairment in endosome membrane invagination and formation of multivesicular bodies (MVBs). hrs mutant animals fail to degrade active epidermal growth factor (EGF) and Torso TKRs, leading to enhanced signaling and altered embryonic patterning. These data suggest that Hrs and MVB formation function to downregulate TKR signaling.}, address = {Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.}, author = {Lloyd, T. E. and Atkinson, R. and Wu, M. N. and Zhou, Y. and Pennetta, G. and Bellen, H. J.}, citeulike-article-id = {353325}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11832215}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11832215}, day = {25}, issn = {0092-8674}, journal = {Cell}, keywords = {endosome, formation, mvb}, month = {January}, number = {2}, pages = {261--269}, posted-at = {2005-10-17 22:35:22}, priority = {2}, title = {Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11832215}, volume = {108}, year = {2002} }

TY - JOUR ID - citeulike:353325 L3 - citeulike-article-id:353325 N2 - Signaling through tyrosine kinase receptors (TKRs) is thought to be modulated by receptor-mediated endocytosis and degradation of the receptor in the lysosome. However, factors that regulate endosomal sorting of TKRs are largely unknown. Here, we demonstrate that Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) is one such factor. Electron microscopy studies of hrs mutant larvae reveal an impairment in endosome membrane invagination and formation of multivesicular bodies (MVBs). hrs mutant animals fail to degrade active epidermal growth factor (EGF) and Torso TKRs, leading to enhanced signaling and altered embryonic patterning. These data suggest that Hrs and MVB formation function to downregulate TKR signaling. IS - 2 JF - Cell SN - 0092-8674 AD - Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. EP - 269 TI - Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. VL - 108 SP - 261 KW - endosome KW - formation KW - mvb AU - Lloyd, TE AU - Atkinson, R AU - Wu, MN AU - Zhou, Y AU - Pennetta, G AU - Bellen, HJ PY - 2002/01/25/ UR - http://view.ncbi.nlm.nih.gov/pubmed/11832215 ER -