Tumor Suppressor Properties of the ESCRT-II Complex Component Vps25 in Drosophila Export

@article{citeulike:487576, abstract = {SummaryWe have found that the Drosophila gene vps25 possesses several properties of a tumor suppressor. First, vps25 mutant cells activate Notch and Dpp receptor signaling, inducing ectopic organizers in developing eyes and limbs and consequent overproliferation of both mutant and nearby wild-type cells. Second, as the mutant cells proliferate, they lose their epithelial organization and undergo apoptosis. Strikingly, when apoptosis of mutant cells is blocked, tumor-like overgrowths are formed that are capable of metastasis. vps25 encodes a component of the ESCRT-II complex, which sorts membrane proteins into multivesicular bodies during endocytic trafficking to the lysosome. Activation of Notch and Dpp receptor signaling in mutant cells results from an endocytic blockage that causes accumulation of these receptors and other signaling components in endosomes. These results highlight the importance of endocytic trafficking in regulating signaling and epithelial organization and suggest a possible role for ESCRT components in human cancer.}, author = {Thompson, Barry J. and Mathieu, Juliette and Sung, Hsin-Ho and Loeser, Eva and Rorth, Pernille and Cohen, Stephen M.}, citeulike-article-id = {487576}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.devcel.2005.09.020}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6WW3-4HFS8TJ-J/2/881389157dd84bed221df384fe04eacb}, doi = {10.1016/j.devcel.2005.09.020}, journal = {Developmental Cell}, keywords = {drosophila, escrtii}, month = {November}, number = {5}, pages = {711--720}, posted-at = {2006-01-31 18:07:37}, priority = {2}, title = {Tumor Suppressor Properties of the ESCRT-II Complex Component Vps25 in Drosophila}, url = {http://dx.doi.org/10.1016/j.devcel.2005.09.020}, volume = {9}, year = {2005} }

TY - JOUR ID - citeulike:487576 L3 - citeulike-article-id:487576 N2 - SummaryWe have found that the Drosophila gene vps25 possesses several properties of a tumor suppressor. First, vps25 mutant cells activate Notch and Dpp receptor signaling, inducing ectopic organizers in developing eyes and limbs and consequent overproliferation of both mutant and nearby wild-type cells. Second, as the mutant cells proliferate, they lose their epithelial organization and undergo apoptosis. Strikingly, when apoptosis of mutant cells is blocked, tumor-like overgrowths are formed that are capable of metastasis. vps25 encodes a component of the ESCRT-II complex, which sorts membrane proteins into multivesicular bodies during endocytic trafficking to the lysosome. Activation of Notch and Dpp receptor signaling in mutant cells results from an endocytic blockage that causes accumulation of these receptors and other signaling components in endosomes. These results highlight the importance of endocytic trafficking in regulating signaling and epithelial organization and suggest a possible role for ESCRT components in human cancer. IS - 5 JF - Developmental Cell EP - 720 TI - Tumor Suppressor Properties of the ESCRT-II Complex Component Vps25 in Drosophila VL - 9 SP - 711 KW - drosophila KW - escrtii AU - Thompson, Barry AU - Mathieu, Juliette AU - Sung, Hsin-Ho AU - Loeser, Eva AU - Rorth, Pernille AU - Cohen, Stephen PY - 2005/11// UR - http://dx.doi.org/10.1016/j.devcel.2005.09.020 ER -