Tunability and noise dependence in differentiation dynamics. Export

@article{citeulike:1188027, abstract = {The dynamic process of differentiation depends on the architecture, quantitative parameters, and noise of underlying genetic circuits. However, it remains unclear how these elements combine to control cellular behavior. We analyzed the probabilistic and transient differentiation of Bacillus subtilis cells into the state of competence. A few key parameters independently tuned the frequency of initiation and the duration of competence episodes and allowed the circuit to access different dynamic regimes, including oscillation. Altering circuit architecture showed that the duration of competence events can be made more precise. We used an experimental method to reduce global cellular noise and showed that noise levels are correlated with frequency of differentiation events. Together, the data reveal a noise-dependent circuit that is remarkably resilient and tunable in terms of its dynamic behavior.}, author = {S\"{u}el, G\"{u}rol M. and Kulkarni, Rajan P. and Dworkin, Jonathan and Garcia-Ojalvo, Jordi and Elowitz, Michael B.}, citeulike-article-id = {1188027}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1137455}, citeulike-linkout-1 = {http://www.sciencemag.org/content/315/5819/1716.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/315/5819/1716.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/315/5819/1716}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/17379809}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=17379809}, day = {23}, doi = {10.1126/science.1137455}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {differentiation, dynamics, noise}, month = {March}, number = {5819}, pages = {1716--1719}, posted-at = {2007-03-30 08:55:08}, priority = {1}, title = {Tunability and noise dependence in differentiation dynamics.}, url = {http://dx.doi.org/10.1126/science.1137455}, volume = {315}, year = {2007} }

TY - JOUR ID - citeulike:1188027 L3 - citeulike-article-id:1188027 N2 - The dynamic process of differentiation depends on the architecture, quantitative parameters, and noise of underlying genetic circuits. However, it remains unclear how these elements combine to control cellular behavior. We analyzed the probabilistic and transient differentiation of Bacillus subtilis cells into the state of competence. A few key parameters independently tuned the frequency of initiation and the duration of competence episodes and allowed the circuit to access different dynamic regimes, including oscillation. Altering circuit architecture showed that the duration of competence events can be made more precise. We used an experimental method to reduce global cellular noise and showed that noise levels are correlated with frequency of differentiation events. Together, the data reveal a noise-dependent circuit that is remarkably resilient and tunable in terms of its dynamic behavior. IS - 5819 JF - Science (New York, N.Y.) SN - 1095-9203 EP - 1719 TI - Tunability and noise dependence in differentiation dynamics. VL - 315 SP - 1716 KW - differentiation KW - dynamics KW - noise AU - Süel, Gürol AU - Kulkarni, Rajan AU - Dworkin, Jonathan AU - Garcia-Ojalvo, Jordi AU - Elowitz, Michael PY - 2007/03/23/ UR - http://dx.doi.org/10.1126/science.1137455 ER -