Integrating Expression Data with Domain Interaction Networks Export

@article{citeulike:3153104, abstract = {Summry: Recent studies have revealed that alternative splicing plays an important role in the observed protein and interaction diversity. Spe-cial microarrays allow for measuring gene expression at the exon level and thus for studying alternative transcripts and their corre-sponding protein domain architecture. We have developed the Cytoscape plugin DomainGraph that enables the visualization and detailed study of domain-domain interactions forming protein inter-action networks. In addition, the integration of exon expression data supports the analysis of alternative splicing events and the charac-terization of their effects on the protein and domain interaction net-work. Different expression patterns between human tissues or cells can be identified by comparing the generated domain graphs. Availability: The plugin DomainGraph and the online documentation are avail-able at http://domaingraph.bioinf.mpi-inf.mpg.de. Contact: mario.albrecht@mpi-inf.mpg.de 10.1093/bioinformatics/btn437}, author = {Emig, Dorothea and Cline, Melissa S. and Lengauer, Thomas and Albrecht, Mario}, citeulike-article-id = {3153104}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/bioinformatics/btn437}, citeulike-linkout-1 = {http://bioinformatics.oxfordjournals.org/cgi/content/abstract/24/21/2546}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18710874}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18710874}, day = {19}, doi = {10.1093/bioinformatics/btn437}, journal = {Bioinformatics}, keywords = {domain, interaction, network}, month = {August}, pages = {btn437+}, posted-at = {2008-10-28 13:43:17}, priority = {3}, title = {Integrating Expression Data with Domain Interaction Networks}, url = {http://dx.doi.org/10.1093/bioinformatics/btn437}, year = {2008} }

TY - JOUR ID - citeulike:3153104 L3 - citeulike-article-id:3153104 N2 - Summry: Recent studies have revealed that alternative splicing plays an important role in the observed protein and interaction diversity. Spe-cial microarrays allow for measuring gene expression at the exon level and thus for studying alternative transcripts and their corre-sponding protein domain architecture. We have developed the Cytoscape plugin DomainGraph that enables the visualization and detailed study of domain-domain interactions forming protein inter-action networks. In addition, the integration of exon expression data supports the analysis of alternative splicing events and the charac-terization of their effects on the protein and domain interaction net-work. Different expression patterns between human tissues or cells can be identified by comparing the generated domain graphs. Availability: The plugin DomainGraph and the online documentation are avail-able at http://domaingraph.bioinf.mpi-inf.mpg.de. Contact: mario.albrecht@mpi-inf.mpg.de 10.1093/bioinformatics/btn437 JF - Bioinformatics TI - Integrating Expression Data with Domain Interaction Networks SP - btn437 KW - domain KW - interaction KW - network AU - Emig, Dorothea AU - Cline, Melissa AU - Lengauer, Thomas AU - Albrecht, Mario PY - 2008/08/19/ UR - http://dx.doi.org/10.1093/bioinformatics/btn437 ER -