Homologous Recombination as an Evolutionary Force in the Avian Influenza A Virus Export

@article{citeulike:3851799, abstract = {Avian influenza A viruses (AIVs), including the H5N1, H9N2, and H7N7 subtypes, have been directly transmitted to humans, raising concerns over the possibility of a new influenza pandemic. To prevent a future avian influenza pandemic, it is very important to fully understand the molecular basis driving the change in AIV virulence and host tropism. Although virulent variants of other viruses have been generated by homologous recombination, the occurrence of homologous recombination within AIV segments is controversial and far from proven. This study reports three circulating H9N2 AIVs with similar mosaic PA genes descended from H9N2 and H5N1. Additionally, many homologous recombinants are also found deposited in GenBank. Recombination events can occur in PB2, PB1, PA, HA, and NP segments and between lineages of the same/different serotype. These results collectively demonstrate that intragenic recombination plays a role in driving the evolution of AIVs, potentially resulting in effects on AIV virulence and host tropism changes. 10.1093/molbev/msn238}, author = {He, Cheng-Qiang and Xie, Zhi-Xun and Han, Guan-Zhu and Dong, Jian-Bao and Wang, Dong and Liu, Jia-Bo and Ma, Le-Yuan and Tang, Xiao-Fei and Liu, Xi-Ping and Pang, Yao-Shan and Li, Guo-Rong}, citeulike-article-id = {3851799}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/molbev/msn238}, citeulike-linkout-1 = {http://mbe.oxfordjournals.org/cgi/content/abstract/26/1/177}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18931384}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18931384}, day = {1}, doi = {10.1093/molbev/msn238}, journal = {Mol Biol Evol}, keywords = {evolution, influenza, virus}, month = {January}, number = {1}, pages = {177--187}, posted-at = {2009-01-06 05:18:08}, priority = {2}, title = {Homologous Recombination as an Evolutionary Force in the Avian Influenza A Virus}, url = {http://dx.doi.org/10.1093/molbev/msn238}, volume = {26}, year = {2009} }

TY - JOUR ID - citeulike:3851799 L3 - citeulike-article-id:3851799 N2 - Avian influenza A viruses (AIVs), including the H5N1, H9N2, and H7N7 subtypes, have been directly transmitted to humans, raising concerns over the possibility of a new influenza pandemic. To prevent a future avian influenza pandemic, it is very important to fully understand the molecular basis driving the change in AIV virulence and host tropism. Although virulent variants of other viruses have been generated by homologous recombination, the occurrence of homologous recombination within AIV segments is controversial and far from proven. This study reports three circulating H9N2 AIVs with similar mosaic PA genes descended from H9N2 and H5N1. Additionally, many homologous recombinants are also found deposited in GenBank. Recombination events can occur in PB2, PB1, PA, HA, and NP segments and between lineages of the same/different serotype. These results collectively demonstrate that intragenic recombination plays a role in driving the evolution of AIVs, potentially resulting in effects on AIV virulence and host tropism changes. 10.1093/molbev/msn238 IS - 1 JF - Mol Biol Evol EP - 187 TI - Homologous Recombination as an Evolutionary Force in the Avian Influenza A Virus VL - 26 SP - 177 KW - evolution KW - influenza KW - virus AU - He, Cheng-Qiang AU - Xie, Zhi-Xun AU - Han, Guan-Zhu AU - Dong, Jian-Bao AU - Wang, Dong AU - Liu, Jia-Bo AU - Ma, Le-Yuan AU - Tang, Xiao-Fei AU - Liu, Xi-Ping AU - Pang, Yao-Shan AU - Li, Guo-Rong PY - 2009/01/01/ UR - http://dx.doi.org/10.1093/molbev/msn238 ER -